赵明，研究员，博士研究生导师，长聘副教授。曾获国家科学技术进步奖二等奖（2017年），湖南省自然科学奖一等奖（2015年）、湖南省科学技术进步奖一等奖（2018年）等国家和省部级科技奖励6项。获得国家“万人计划”科技创新领军人才、国家自然科学基金优秀青年基金、科技部中青年科技创新领军人才、国家自然科学基金重点项目、江苏省双创人才等项目资助。 皇冠体育投注_皇冠体育app￥比分官网直播：引进人才，2022年加入皇冠体育投注_皇冠体育app￥比分官网直播：，曾在中南大学湘雅二医院（引进前单位）任研究员。

长期从事免疫炎症性皮肤病发病机制及诊断与治疗研究。揭示了红斑狼疮、银屑病发病的表观遗传学机制，研发国际上首个红斑狼疮DNA甲基化诊断试剂盒（已获III类医疗器械证），开发红斑狼疮及银屑病治疗候选新药物。承担9项国家和省部级科研课题，作为通讯作者及第一作者在Journal of Clinical Investigation等杂志发表论文80余篇，H指数50，入选2024年“全球前2%顶尖科学家”。获得授权发明专利17项（已转化2项）。参编专著5部。培养博士、硕士、博士后50余名。

皇冠体育投注_皇冠体育app￥比分官网直播

1. Min X#, Yu Y#, Hu Z, Ouyang L, Qiu Y, Zhao H, Wu J, Zou C, Zheng M, Yang S, Jia S, Yu D, Lu Q*, Zhao M*. DNA demethylation mediated endogenous retroviruses transcription promotes aberrant T cell differentiation in systemic lupus erythematosus via RIG-I pathway. EBioMedicine. 2025 Oct; 120:105934. (IF= 10.8)

2. Qiu Y#, Jiang W, Feng D, Yu Y, Hou H, Deng M, Chen X, Liu L, Wu R, Lu Q*, Zhao M*. Resolving 3-Dimensional Genomic Landscape of CD4+ T Cells in the Peripheral Blood of Patients with Psoriasis. J Invest Dermatol. 2025 Apr; 145(4):831-841. (IF= 5.7)

3. Yin H#, Li L#, Feng X#, Wang Z, Zheng M, Zhao J, Fan X, Wu W, Gao L, Zhan Y, Zhao M*, Lu Q*. 2D4, a humanized monoclonal antibody targeting CD132, is a promising treatment for systemic lupus erythematosus. Signal Transduct Target Ther. 2024 Nov 17; 9(1):323. (IF= 40.8)

4. Wang L#, Yin H, Jiang J, Li Q, Gao C, Li W, Zhang B, Xin Y, Li H, Zhao M*, Lu Q*. A rationally designed CD19 monoclonal antibody-triptolide conjugate for the treatment of systemic lupus erythematosus. Acta Pharm Sin B. 2024 Oct;14(10):4560-4576. (IF= 14.7)

5. Jiang W#, Zhang T#, Qiu Y, Liu Q, Chen X, Wang Q, Min X, Ouyang L, Jia S, Lu Q, He Y*, Zhao M*. Keratinocyte-to-macrophage communication exacerbate psoriasiform dermatitis via LRG1-enriched extracellular vesicles. Theranostics. 2024 Jan 1;14(3):1049-1064. (IF= 12.4)

6. Zhao M#*, Feng D, Hu L, Liu L, Wu J, Hu Z, Long H, Kuang Q, Ouyang L, Lu Q*. 3D genome alterations in T cells associated with disease activity of systemic lupus erythematosus. Ann Rheum Dis. 2023 Feb;82(2):226-234. (IF=20.3, F1000)

7. Zheng M#, Hu Z#, Mei X#, Ouyang L#, Song Y#, Zhou W, Kong Y, Wu R, Rao S, Long H, Shi W, Jing H, Lu S, Wu H, Jia S, Lu Q*, Zhao M*. Single-cell sequencing shows cellular heterogeneity of cutaneous lesions in lupus erythematosus. Nat Commun. 2022 Dec 5;13(1):7489. （IF=17.694）

8. Gao X#, Song Y#, Wu J, Lu S, Min X, Liu L, Hu L, Zheng M, Du P, Yu Y, Long H, Wu H, Jia S, Yu D, Lu Q*, Zhao M*. Iron-dependent epigenetic modulation promotes pathogenic T cell differentiation in lupus. J Clin Invest. 2022 May 2;132(9):e152345. (IF=15.9)

9. Wu R#, Zeng J#, Yuan J, Deng X, Huang Y, Chen L, Zhang P, Feng H, Liu Z, Wang Z, Gao X, Wu H, Wang H, Su Y, Zhao M*, Lu Q*. MicroRNA-210 overexpression promotes psoriasis-like inflammation by inducing Th1 and Th17 cell differentiation. J Clin Invest. 2018 Jun 1;128(6):2551-2568. (IF=11.864, ESI, C100)

10. Zhao M#, Zhou Y, Zhu B, Wan M, Jiang T, Tan Q, Liu Y, Jiang J, Luo S, Tan Y, Wu H, Renauer P, Del Mar Ayala Gutiérrez M, Castillo Palma MJ, Ortega Castro R, Fernández-Roldán C, Raya E, Faria R, Carvalho C, Alarcón-Riquelme ME, Xiang Z, Chen J, Li F, Ling G, Zhao H, Liao X, Lin Y, Sawalha AH*, Lu Q*. IFI44L promoter methylation as a blood biomarker for systemic lupus erythematosus. Ann Rheum Dis. 2016 Nov;75(11):1998-2006. (IF=12.811, R, C100)